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TEM image of PtNPs uptake by A549 cells (A) 3 h and (B) 24 h treatment (Scale bar: whole cell, 2 nm). The scale was enlarged to focus on the nucleus (500 µm). Red arrows indicate the accumulation of PtNPs. PtNPs can penetrate the cells as early as 3 h however the cells keep accumulating in the cytoplasm and nucleus in prolonged treatment (24 h).
