Table 2.

Clinical dosage and renal adjustment for anti-pseudomonal agents.

Drug	Clinical Dosage	Comments
Ceftolozane-tazobactam	1.5 g (ceftolozane 1 g/tazobactam 0.5 g) intravenous every 8 h over 1 h 3 g (ceftolozane 2 g/tazobactam 1 g) intravenous every 8 h over 1 h for HAP/VAP	Extended infusion (over 3 h) 1.5 g or 3 g every 8 h is recommended [46] Renal adjustment with CrCl < 50 mL/min
Ceftazidime-avibactam	2.5 g (ceftazidime 2 g/avibactam 0.5 g) intravenous every 8 h over 2 h	Extended infusion (over 3 h) 2.5 g every 8 h is recommended [46] Renal adjustment with CrCl < 50 mL/min
Cefiderocol	2 g intravenous every 8 h over 3 h	Renal adjustment with CrCl < 60 mL/min
Imipenem-cilastatin-relebactam	1.25 g (imipenem 500 mg/cilastatin 500 mg/relebactam 250 mg) intravenous every 6 h over 30 min	Renal adjustment with CrCl < 90 mL/min
Meropenem-vaborbactam	4 g (meropenem 2 g/vaborbactam 2 g) intravenous every 8 h over 3 h	Renal adjustment with CrCl < 50 mL/min
Plazomicin	15 mg/kg every 24 h over 30 min	Renal adjustment with CrCl < 60 mL/min
Fosfomycin	6–8 g loading dose intravenous, followed by 16 g/day [152]	Renal adjustment with CrCl < 40 mL/min