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. 2022 May 11;11(5):947. doi: 10.3390/antiox11050947

Figure 7.

Figure 7

Effect of baicalein on the protein levels of BDNF and CREB in the hippocampi of mice. (A) Western blots showing levels of mBDNF and proBDNF. The levels of mBDNF (B) and the ratio of mBDNF/proBDNF (C) in the hippocampus decreased significantly after the administration of LPS (5 mg/kg, i.p.). Treatment with baicalein (3 mg/kg, i.p.) 1 h following LPS administration could inhibit the reduction. The levels of proBDNF (D) did not differ among the groups. (E) Western blots showing levels of CREB. Baicalein promoted a significant increase in the expression of CREB protein (F), as observed in LPS-Baicalein-treated mice. Data are presented as means ± SEM. (n = 8) * p < 0.05, ** p < 0.01, *** p < 0.001.