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. 2022 May 26;17(1):978–990. doi: 10.1515/med-2022-0487

Figure 1.

Figure 1

Rack1 was highly expressed in DN in vivo and in vitro. (a) The mRNA was examined by RNA-seq (q < 0.05) in the kidney tissues of db/db DN mice (n = 3 for 12 weeks) and normal control mice (n = 2 for 12 weeks). A total of 6,820 mRNAs were dysexpressed in the DN group, including 3,905 up-expressed and 2,915 down-expressed mRNAs (q-value <0.05). (b) Fifty-seven DN-related genes were found with high fold changes (|fold change| >1) and high values of FPKM in both two groups (FPKM > 100) by RNA-seq. (c) The expression of Rack1 was significantly increased in renal tissues of the DN mice group compared with that in the normal controls by RNA-seq (**p < 0.01). (d) The expression of Rack1 was significantly increased in renal tissues of the DN mice group compared with that in the normal controls by qRT-PCR. The data are representative of three independent experiments (**p < 0.01).