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. 2022 Apr 25;11(5):832. doi: 10.3390/antiox11050832

Figure 1.

Figure 1

Protective effect of BCE against in vitro RPE damage model. (A) Effect of BCE on ARPE-19 cell viability. Cells were treated with BCE (20–80 μg/mL) for 72 h. * p < 0.05 vs. CTR. (B,C) ARPE-19 cells were treated with A2E three times at 48 h intervals, and 24 h after the last treatment, BCE (10–50 μg/mL) was treated twice at 24 h intervals. After 30 min of BL irradiation, the cells were recovered for 24 h. Cells were monitored using the IncuCyte Zoom imaging system. Lutein (15 μg/mL) was used as a positive control. The results are presented as the mean ± standard deviation of three independent experiments (n = 3). ### p < 0.001 vs. CTR, * p < 0.05, ** p < 0.01, *** p < 0.001 vs. A2E + BL. CTR, no treatment control; A, A2E; BL, blue light; AB, A2E + BL; Lu, lutein (15 μg/mL); BCE (10), BCE, 10 μg/mL; BCE (25), BCE, 25 μg/mL; BCE (50), BCE, 50 μg/mL; A2E, N-retinylidene-N-retinylethanolamine; BL, blue light; BCE, Blackcurrant extract.