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(A) 2D diagram of the syncrystalized drug voriconazole in 14-alpha demethylase (CYP51B) from the fungus Aspergillus fumigatus. (B) Superposition of most active compounds 8 (magenta), 7 (orange), and voriconazole (grey) 14-alpha demethylase (CYP51B) from the fungus Aspergillus fumigatus. Green arrows indicate a hydrogen bond; yellow spheres indicate the hydrophobic interactions, and the blue line indicates Fe-binding.
