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. 2022 Apr 24;11(5):829. doi: 10.3390/antiox11050829

Figure 4.

Figure 4

Se-FA reduces the levels of lipids, lipoproteins and MDA in the serum or brain of AD mice. (a,b) Levels of TC, TG, LDL-C, and HDL-C in the serum of 7-month-old 3×Tg- (a) and 2×Tg-AD mice (b) measured by an automated chemistry analyzer (n = 3 or 5 mice). (c,d) ApoE levels in the cortex (c), hippocampus (c) and serum (d) of 7-month-old 3×Tg-AD mice measured by ELISA (n = 3 or 5 mice). (e) ApoJ levels in the cortex and hippocampus of 7-month-old 3×Tg-AD mice measured by ELISA (n = 3 or 5 mice). (f–i) Levels of MDA (f,g) and 4-HNE (h,i) in the cortex and hippocampus of 3×Tg- (f,h) and 2×Tg-AD mice (g,i) measured by ELISA (n = 3, 4 or 5 mice). All the mice were fed diets with Se-FA or a control diet for 12 weeks. All data are presented as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 as determined by one-way ANOVA followed by Dunnett’s multiple comparison test.