Table 2.
Hydrodynamic diameter (DH), polydispersity index (PDI), transition temperature and DOX encapsulation efficiency (EE%) of DOX-loaded SMLs based on different lipid formulations at 25 °C.
| Group | Lipid Composition | DH (nm) | PDI | EE% | Isoelectric pt. | Tm (°C) |
|---|---|---|---|---|---|---|
| A | DPPC | 116 ± 3 | 0.18 ± 0.02 | 96.9 ± 0.5 | 7.80 | 41.40 ± 0.02 |
| DPPC/CHEMS | 149 ± 7 | 0.21 ± 0.01 | 95 ± 1 | 5.61 | 38.2 ± 0.2 | |
| DPPC/CHEMS/DSPE-PEG | 156 ± 18 | 0.20 ± 0.02 | 94 ± 3 | 6.22 | 41.34 ± 0.02 | |
| B | DPPC/DSPC | 157 ± 1 | 0.22 ± 0.03 | 88 ± 2 | 5.95 | 42.4 ± 0.2 |
| DPPC/DSPC/CHEMS | 160 ± 1 | 0.20 ± 0.01 | 92 ± 2 | 5.37 | 39.7 ± 0.1 | |
| DPPC/DSPC/CHEMS/DSPE-PEG | 187 ± 4 | 0.22 ± 0.02 | 92 ± 5 | 5.61 | 41.4 ± 0.2 | |
| C | DPPC/DOPE | 111 ± 17 | 0.24 ± 0.07 | 96.7 ± 0.5 | 8.00 | * |
| DPPC/DOPE/CHEMS | 118 ± 4 | 0.20 ± 0.04 | 87 ± 12 | 5.49 | * | |
| DPPC/DOPE/CHEMS/DSPE-PEG | 117.39 ± 0.03 | 0.23 ± 0.06 | 93 ± 4 | 5.13 | * |
* Tm peak not found.