Table 3.
Summary of release slope (m) values of DOX plotted in the first 5 h and ratio between the saturation release under 37 °C, pH 7.4 and the corresponding release conditions.
| Group | Lipid Composition | 42 °C, pH 5.5 | 42 °C, pH 7.4 | 37 °C, pH 5.5 | 37 °C, pH 7.4 | ||||
|---|---|---|---|---|---|---|---|---|---|
| m | Ratio | m | Ratio | m | Ratio | m | Ratio | ||
| A | DPPC | 4.04 | 5.67 | 1.77 | 1.47 | 1.30 | 2.21 | 0.68 | 1 |
| DPPC/CHEMS | 6.39 | 1.91 | 2.58 | 1.12 | 5.92 | 1.25 | 2.70 | 1 | |
| DPPC/CHEMS/DSPE-PEG | 4.71 | 2.30 | 2.39 | 1.54 | 3.53 | 1.74 | 2.52 | 1 | |
| B | DPPC/DSPC | 6.39 | 1.86 | 2.32 | 0.59 | 5.89 | 1.12 | 2.7 | 1 |
| DPPC/DSPC/CHEMS | 4.23 | 2.88 | 1.77 | 1.51 | 5.25 | 2.92 | 0.98 | 1 | |
| DPPC/DSPC/CHEMS/DSPE-PEG | 7.21 | 1.75 | 1.74 | 0.93 | 6.19 | 1.71 | 2.11 | 1 | |
| C | DPPC/DOPE | 4.04 | 2.48 | 2.70 | 2.01 | 4.20 | 1.88 | 0.79 | 1 |
| DPPC/DOPE/CHEMS | 5.83 | 2.42 | 3.26 | 1.48 | 3.15 | 1.37 | 2.67 | 1 | |
| DPPC/DOPE/CHEMS/DSPE-PEG | 3.42 | 1.66 | 1.69 | 0.93 | 1.83 | 1.82 | 1.03 | 1 | |