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. 2022 Apr 19;12(5):604. doi: 10.3390/biom12050604

Figure 2.

Figure 2

Increased levels of MMP-2 and MMP-8 in TAF samples correlated with non-survival COVID-19 and shed of sHLA-G and sTREM-1. (A) Quantification of MMP-2 and MMP-8 in TAF samples from non-COVID-19 (n = 13) and COVID-19 patients (survival n = 6, non-survival n = 33). Statistical analyzes were performed using the Kruskal–Wallis multiple comparison test, followed by the Dunns post-test to compare pairs. Data are expressed as median with 95% confidence intervals. Statistical differences between groups are considered by p < 0.05 and represented directly in the graphic figure. (B) Correlations between MMP-2 and MMP-8 levels and soluble immune factors sHLA-G and sTREM-1 in total TAF samples from non-COVID-19 and COVID-19 patients at hospital admission. (C) Correlations between MMP-2 and MMP-8 levels in total TAF samples from non-COVID-19 and COVID-19 patients at hospital admission. Spearman correlation analysis, r and p value indicated in each panel. (D) Schematic representation of the MMP-2 and MMP-8 positive looping inducing the release of sHLA-G and sTREM-1 in lung from severe COVID-19. (Created with BioRender.com, Agreement number: IZ23RHRAES).