Figure 6.
Bubble plots of gene enrichment results from the top CpG sites (unadjusted p < 0.005 and |∆β| ≥ 0.05; mapped to 258 genes) associated with opioid exposure. (A) The top 15 Gene Ontology (GO) enrichment terms. GO terms are color-coded by subcategory (Biological Process vs. Cellular Component). All unadjusted p ≤ 6.4 × 10−4 and all adjusted p ≤ 0.054. Ten GO enrichment terms met the adjusted threshold for significance (p < 0.05). (B) The top 6 Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms. The size of the bubble for each enrichment term corresponds to the number of enriched genes within that pathway. None of the KEGG enrichment terms reached the adjusted significance threshold.