Table 1.
Glial and neuronal receptors involved in extracellular α-syn uptake in the CNS.
| Receptor | α-Syn Conformer | Cell Type | Reference |
|---|---|---|---|
| Lymphocyte-activation gene 3 (LAG3) | Fibrils | Neuron, microglia | [63,121] |
| Cellular prion protein (PrPc) | Fibrils, soluble oligomers | Neurons | [122,123] |
| Heparan sulfate | Fibrils | Neuron, oligodendrocytes | [64] |
| Toll-like receptor 4 (TLR4) | n.d. | Microglia | [61] |
| Toll-like receptor 2 (TLR2) | Soluble oligomers | Microglia | [118] |
| a3-subunit of Na+/K+-ATPase | Fibrils, soluble oligomers | Neurons | [124] |
| FcƔRIIB | Fibrils | Microglia, neurons | [125] |