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. 2022 May 20;11(5):779. doi: 10.3390/biology11050779

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Digital colored TEM of the macrophages in the spleen. (A,B) Macrophages (red) displayed long pseudopodia and their cytoplasm contained many lysosomes (black arrowheads) and other phagocytosed materials (white arrowheads). They were usually associated with dendritic cells (blue, D) and neutrophils (pink, N). (C) The active phagocytosing macrophages (red) were characterized by the kidney-shaped nucleus, vacuoles (black arrowheads), and phagocytosed materials (white arrowheads). Note the presence of neutrophils (pink, N). (D) They were merged into spherical structures known as melanomacrophage centers (MMCs, red) with vesicles containing pigments (arrowheads).