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. 2022 May 11;10(5):1118. doi: 10.3390/biomedicines10051118

Figure 2.

Figure 2

Mean intracellular calcium level changes in RASF in response to THC. (A) Intracellular calcium mobilization without TNF pre–stimulation. (B,C) Intracellular calcium level regulated by THC (0.1−25 µM) with TNF (10 ng/mL) pre–stimulation for 72 h and extracellular calcium (HBSS; (B–G)) or without calcium (PBS; (H–M)). *** p < 0.001, ** p < 0.01, * p < 0.05 for differences between antagonist treatment and control (THC only). (B,H) Comparisons of different THC concentrations versus control (no THC). Significant values are given in the graph. ANOVA with Bonferroni post hoc test was used for all comparisons. Rimonanbant, CB1 inverse agonist; COR170, CB2 inverse agonist; A967079, TRPA1 antagonist; HC-030031, TRPA1 antagonist; RR = Ruthenium Red, general TRP inhibitor.