Table 3.
Summary of findings: Effect of Vitamin K on bone mineral density and fracture risk in adults.
| Outcomes | Absolute Effect | Relative Effect (95% CI) |
Number of Studies | Certainty of the Evidence (GRADE) | |
|---|---|---|---|---|---|
| Without Vit K (CONTROL) |
With Vit K (Vitamin K) |
||||
| BMD | 554 | 548 | RR [OR] (−0.03) to (0.2) |
[5] | ⊕⊕⊕⊖ Moderate |
|
Difference: 95% CI: [−0.03] to [0.2] | |||||
| Clinical Fracture |
33 Per 332 |
15 per 318 |
RR [OR] (0.23) to (0.84) |
[4] | ⊕⊕⊖⊖ Low |
|
Difference: 95% CI: [0.23] to [0.84] | |||||
| Vertebral Fracture |
64 per 311 |
29 per 298 |
RR [OR] (0.27) to (0.66) |
[4] | ⊕⊕⊖⊖ Low |
|
Difference: 95% CI: [0.27] to [0.66] | |||||
People: Adults defined as over 18 years of age. Settings: Postmenopausal women. Intervention: Vitamin K. Comparison: Control include no treatment, treatment as usual, placebo, calcium, Vitamin D, hormone. Replacement therapies, bisphosphonates.