Figure 5.

Hyperthermia enhances the cytotoxic effect of chemotherapeutic agents. Heatmap displaying the ${\mathrm{IC}}_{50,\mathrm{ratio}, \mathrm{drug}}$ which represent the combined effect of hyperthermia and chemotherapy compared to single therapy (drug administered at 37 °C). Data are expressed as a percentage of ${\mathrm{IC}}_{50,\mathrm{drug}}$ at 37 °C experimental conditions. X indicates data not available (A). Dose reduction index values are plotted in (B) to further confirm the results expressed as relative ${\mathrm{IC}}_{50,\mathrm{ratio}, \mathrm{drug}}$. Unfavorable: DRI < 0.8; Moderate unfavorable: 0.8 < DRI > 0.85; Mild unfavorable: 0.85 < DRI > 0.9; No dose reduction: 0.9 < DRI > 1.1; Mild Favorable: 1.1 < DRI > 1.3; Moderate favorable 1.3 < DRI > 1.8; Favorable DRI > 1.8. X indicates data not available.