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Hyperthermia leads to downregulation of RRM2, TS, and ERCC1. Relative expression of RRM1, TS, and ERCC1 in (A) BxPC-3 cells and (B) Capan-2 cells. Expression is normalized to GAPDH and calculated relative to cells incubated at 37 °C. Statistical significance ns = not significant; * p < 0.05; *** p < 0.0001; **** p < 0.00001.
