Table 2.
Univariate Analyses of Factors Associated with Brain Metastasis Free Survival (BMFS) and Overall Survival (OS) in Patients with Limited-Stage Small Cell Lung Cancer (LS-SCLC) After Prophylactic Cranial Irradiation (PCI)
| Factors | BMFS | OS | ||||
|---|---|---|---|---|---|---|
| 5-Year-BMFS (%) | x2 | P | 5-Year-OS (%) | x2 | P | |
| Age (years) | ||||||
| <60 | 78.1 | 0.628 | 0.428 | 34.1 | 11.182 | 0.001 |
| ≥60 | 76.3 | 25.3 | ||||
| Sex | ||||||
| Male | 78.1 | 0.926 | 0.336 | 31.3 | 0.155 | 0.694 |
| Female | 84.2 | 30.7 | ||||
| Pathologic N stage | ||||||
| N0 | 83.8 | 1.601 | 0.659 | 47.5 | 9.437 | 0.024 |
| N1 | 78.7 | 36.7 | ||||
| N2 | 74.2 | 29.4 | ||||
| N3 | 72.1 | 29.6 | ||||
| Pathologic stage | ||||||
| I | 89.7 | 6.314 | 0.043 | 68.7 | 24.296 | 0.000 |
| II | 88.6 | 48.9 | ||||
| III | 74.1 | 24.7 | ||||
| Primary tumor size | ||||||
| <5 cm | 81.3 | 5.231 | 0.022 | 31.4 | 0.580 | 0.446 |
| ≥5 cm | 71.6 | 28.6 | ||||
| Brain metastases | ||||||
| Yes | / | 8.9 | 15.536 | 0.000 | ||
| No | / | 36.1 | ||||
| Response to ChT | ||||||
| CR | 75.8 | 0.236 | 0.627 | 35.1 | 0.211 | 0.646 |
| PR | 78.2 | 30.2 | ||||
| XRT fractionation | ||||||
| Once Daily | 76.2 | 0.171 | 0.679 | 21.6 | 6.152 | 0.013 |
| Twice Daily | 76.8 | 34.8 | ||||
Abbreviations: ChT, chemotherapy; PCI, prophylactic cranial irradiation; HR, hazard ratio; CI, confidence interval; OS, overall survival; BMFS, brain metastasis free survival; CI, confidence interval.