Table 3.
Multivariate Analyses of Factors Associated with Brain Metastasis Free Survival (BMFS) and Overall Survival (OS) in Patients with Limited-Stage Small Cell Lung Cancer (LS-SCLC) After Prophylactic Cranial Irradiation (PCI)
| Factors | BMFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (years) | ||||||
| <60 | ||||||
| ≥60 | 1.021 | [0.594–1.757] | 0.940 | 1.167 | [0.995–1.214] | 0.074 |
| Sex | ||||||
| Male | ||||||
| Female | 1.801 | [0.769–4.217] | 0.175 | 1.066 | [0.948–1.170] | 0.118 |
| Pathologic N stage | ||||||
| N0 | ||||||
| N1 | ||||||
| N2 | ||||||
| N3 | 1.141 | [0.873–1.305] | 0.751 | 1.187 | [0.993–1.371] | 0.061 |
| Pathologic stage | ||||||
| I | ||||||
| II | ||||||
| III | 1.733 | [1.064–2.823] | 0.027 | 2.072 | [1.607–2.671] | 0.000 |
| Primary tumor size | ||||||
| <5 cm | ||||||
| ≥5 cm | 1.781 | [1.044–3.039] | 0.034 | 1.126 | [0.925–1.663] | 0.182 |
| Brain metastases | ||||||
| Yes | ||||||
| No | — | — | — | 1.795 | [1.304–2.472] | 0.000 |
| Response to ChT | ||||||
| CR | ||||||
| PR | 0.617 | [0.349–1.091] | 0.097 | 1.108 | [0.788–1.557] | 0.555 |
| XRT fractionation | ||||||
| Once Daily | ||||||
| Twice Daily | 0.692 | [0.410–1.166]] | 0.617 | 0.829 | [0.631–1.087] | 0.175 |
Abbreviations: ChT, Response to chemotherapy; PCI, prophylactic cranial irradiation; HR, hazard ratio; CI, confidence interval; OS, overall survival; BMFS, brain metastasis free survival; CI, confidence interval.