Table 4. Factors associated with poor and negative seroconversion responses to the BNT162b2 vaccine.

ARDs: Autoimmune rheumatic diseases; Ab: Antibody.

Medications	Seropositive Ab titer ≥ 0.8 (n = 103)	Negative seroconversion Ab titer < 0.8  (n = 7)	P-value	Seropositive Ab titer ≥ 132  (n = 89)	Poor seroconversion Ab titer < 132 (n = 21)	P-value
Age (years)
< 40	30 (29.1)	5 (71.4)	0.032	26 (29.2)	9 (42.9)	0.227
40-49	31 (30.1)	1 (14.3)	0.671	29 (32.6)	3 (14.3)	0.115
≥ 50	42 (40.8)	1 (14.3)	0.243	34 (38.2)	9 (42.9)	0.805
Sex N (%)
Female	60 (58.3)	6 (85.7)	0.239	54 (60.7)	12 (57.1)	0.766
Male	43 (41.7)	1 (14.3)		35 (39.3)	9 (42.9)
Comorbidities N (%)
Diabetes mellitus	13 (12.6)	2 (28.6)	0.243	11 (12.4)	4 (19)	0.480
Hypertension	24 (23.3)	3 (42.9)	0.359	20 (22.5)	7 (33.3)	0.298
Dyslipidaemia	12 (11.7)	1 (14.3)	1.000	12 (13.5)	1 (4.8)	0.456
Chronic kidney disease	0 (0)	2 (28.6)	0.004	0 (0)	2 (95)	0.004
Chronic heart disease	3 (2.9)	1 (14.3)	0.236	3 (3.4)	1 (4.8)	0.581
Hypothyroidism	9 (8.7)	1 (14.3)	0.497	8 (9)	2 (9.5)	1.000
Obesity	12 (11.7)	2 (28.6)	0.218	12 (13.5)	2 (9.5)	1.000
ARDs N (%)
Rheumatoid arthritis	30 (29.1)	2 (28.6)	0.154	51 (57.3)	9 (42.9)	0.232
Connective tissue disease	31 (30.1)	5 (71.4)	0.000	10 (11.2)	5 (23.8)	0.158
Spondyloarthropathy	42 (40.8)	0 (0)	0.100	26 (29.2)	7 (33.3)	0.711
Other	30 (29.1)	0 (0)	1.000	2 (2.2)	0 (0)	1.000