Figure 5.

(A) Two-step method achieved MRI/NIRF dual-modal imaging [54]. HepG2 cells were incubated with the biotin-conjugated GPC-3 antibodies, and then incubated with dual-modal nanoprobes carrying streptavidin. (B) Anti-GPC-3 PBNPs for targeted MR imaging and photothermal ablation in vitro. (a,b) exhibited images of different concentrations of anti-GPC-3 PBNPs under T₁ and T₂ weighted imaging, and MR imaging after incubated with tumor cells, respectively. Reproduced with permission Ref. [55]. Copyright 2014 Royal Society of Chemistry.