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. 2022 Apr 30;10(5):1038. doi: 10.3390/biomedicines10051038

Figure 2.

Figure 2

MIF promoted the proliferation of MV4-11 through up-regulating the expressions of CXCR2, cytokines and cell division proteins in vitro. (A) Representative flow cytometry (FC) plots of BrdU expression (upper histogram) and CXCR2 expression (lower histogram) in 50 ng/mL MIF-treated MV4-11 cells or non-treatment control (without adding MIF) after 2 days in vitro; (B) Data show the change of mRNA expressions of CXCR2 gene and CXCL1 chemokine gene in MV4-11 cells at 50 ng/mL MIF in vitro; (C) Data show the change of mRNA expressions of CXCL5 and CXCL8 chemokine genes in MV4-11 cells at 50 ng/mL MIF in vitro; (D) Data show the change of mRNA expressions of CDK4 and CYCLIN E1 genes in MV4-11 cells at 50 ng/mL MIF in vitro; (E) Representative FC histogram plot of Ki-67 expression in RAW264.7 experimental groups after 2 days in vitro; Red curve indicates the treated group with 50 ng/mL MIF, showing less expression of Ki-67 when compared to the non-treatment control (gray curve); * p < 0.05, ** p < 0.01.