Table 1.
Information of AML-FLT3 Patients.
| No. | Diagnosis | Age | Sex | Disease Status | Gene Mutations |
|---|---|---|---|---|---|
| #1 | AML | 55 | M | Newly diagnosed | 1. FLT3: 40% allele frequency (c.2503G>T; p.D835Y) 2. NPM1: SR 0.72 (c.863_864insCTTG; p.W288Cfs*12) |
| #2 | AML | 41 | M | Relapsed/Refractory | FLT3 Internal Tandem Duplication (ITD): Allele Frequency: (2 separate mutations) 0.25% & 0.52% |
| #3 | AML | 69 | M | Relapsed/Refractory, On treatment |
1. FLT 3 ITD: SR 0.89 (c.1789delins25; p.Y597delins9) (23% allele frequency) 2.RUNX1: 94% allele frequency (c.602G>A; p.R201Q) 3.IDH2: 65% allele frequency (c.419G>A; p.R140Q) 4. DNMT3A: 48% allele frequency (c.2645G>A; p.R882H) 5.SRSF2: 46% allele frequency (c.284_307del24; p.P95_R102del) |
| #4 | AML | 53 | F | Newly Diagnosed | 1. CBFB-MYH11: Allele Frequency 102.3453% 2. FLT3 (c.1793_1794ins21;p.Y597_E598insDDPSLID): Allele Frequency 0.65% 3. KIT (c.1251_1257dekubsGGCA;p.Y418_D419delinsA): Allele Frequency 2% |
| #5 | AML | 62 | M | Newly diagnosed | 1. FLT3-ITD: Level = 0.98 |
| #6 | AML | 65 | F | Refractory | 1. FLT 3: ITD SR 0.57 2. PHF6: 41% allele frequency (c.821G>A; p.R274Q) 3. RUNX1: 34% allele frequency (c.494_497dup; p.G168Kfs*46) 4. WT1: 82% allele frequency (c.1140dup; p.S381Vfs*4) |