Table 2.
Clinical trials of Dtx-loaded NPs based on https://clinicaltrials.gov/ (accessed on 10 February 2021).
| Nr | Study Title | Cancer | DDS | Phase | Status |
|---|---|---|---|---|---|
| NCT01300533 | A Study of BIND-014 Given to Patients with Advanced or Metastatic Cancer | Metastatic cancer, solid tumours |
NPs | 1 | C |
| NCT02479178 | A Study of BIND-014 in Patients with Urothelial Carcinoma, Cholangiocarcinoma, Cervical Cancer and Squamous Cell Carcinoma of the Head and Neck (iNSITE2) | Urothelial carcinoma cholangiocarcinoma, cervical cancer, squamous cell carcinoma of head and neck | NPs | 2 | T |
| NCT02283320 | A Study of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as Second-line Therapy for Patients with KRAS Positive or Squamous Cell Non-Small Cell Lung Cancer | KRAS-positive patients with non-small cell lung cancer, squamous cell non-small cell lung cancer | NPs | 2 | C |
| NCT01792479 | A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as Second-line Therapy to Patients with Non-Small Cell Lung Cancer | Non-small cell lung cancer | NPs | 2 | C |
| NCT01812746 | A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension), Administered to Patients with Metastatic Castration-Resistant Prostate Cancer | Castration-resistant prostate cancer, prostate cancer |
NPs | 2 | C |
| NCT01151384 | Liposome Encapsulated Docetaxel (LE-DT) in Patients with Solid Tumours (LE-DT) | Solid tumours | Liposomes | 1 | C |
| NCT01186731 | Efficacy and Safety Study of LE-DT to Treat Locally Advanced or Metastatic Pancreatic Cancer | Pancreatic cancer | Liposomes | 2 | C |
| NCT01188408 | Efficacy and Safety Study of LE-DT to Treat Metastatic Castrate Resistant Prostate Cancer | Prostate cancer | Liposomes | 2 | W |
| NCT01103791 | A Trial to Determine the Maximum Tolerated Dose and Evaluate the Safety and Pharmacokinetics of Docetaxel-PNP, Polymeric Nanoparticle Formulation of Docetaxel, in Subjects with Advanced Solid Malignancies | Advanced solid malignancies | NPs | 1 | C |
| NCT03712423 | PET Study With [89Zr]-Df-CriPec® Docetaxel | Solid tumour | CCL-PMs | 1 | C |
| NCT03742713 | Efficacy Study of CPC634 (CriPec® Docetaxel) in Platinum Resistant Ovarian Cancer (CINOVA) | Cancer, ovarian cancer | CCL-PMs | 2 | C |
| NCT02442531 | A Study of CriPec® Docetaxel Given to Patients with Solid Tumours (NAPOLY) | Cancer, metastatic cancer, solid tumours |
CCL-PMs | 1 | C |
CCL-PMs—core-crosslinked polymeric micelles, C—completed, NPs—nanoparticles; T—terminated, W—withdrawn.