Table 3.
Analysis of the risk of bias in animal studies using the SYRCLE RoB tool [42] scale adapted for nerve damage and treated with PHB scaffolds.
| STUDY | Selection Bias | Performance Bias | Detection Bias | Attrition Bias | Reporting Bias | Other | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sequence | Baseline | Allocation | Random Housing | Housing Blinding | Random Outcome Asses. | Outcome Asses. Blinding | Incomplete Outcome Addr. | Sel. Outcome Rep. | Free of Other Problems | |
| Borkenhagen et al., 1998 [13] | U | U | U | U | U | U | U | U | Y | N |
| Ljungberg et al., 1999 [14] | U | Y | N | U | U | U | U | Y | Y | N |
| Hazari et al., 1999a [15] | U | Y | U | U | U | U | U | U | U | N |
| Hazari et al., 1999b [16] | U | U | U | U | U | U | U | U | U | N |
| Young et al., 2002 [17] | U | U | U | U | U | U | U | U | U | Y |
| Mohanna et al., 2003 [18] | U | Y | U | U | U | U | U | U* | Y | Y |
| Hart et al., 2003 [19] | U | U | U | U | U | U | U | U* | U | N |
| Birchall et al., 2004 [20] | U | Y | U | U | U | U | U | U* | Y | Y |
| Mohanna et al., 2005 [21] | U | Y | U | U | U | U | U | U* | Y | N |
| Kalbermatten et al., 2008a [22] | U | U | U | U | U | U | U | U | U | N |
| Kalbermatten et al., 2008b [23] | U | U | U | U | U | U | U | Y | Y | Y |
| Kalbermatten et al., 2008c [24] | U | U | U | U | U | U | U | Y | U | Y |
| Bian et al., 2009 [25] | U | U | U | U | U | U | U | U | U | Y |
| Durgam et al., 2010 [27] | U | Y | U | U | U | U | U | U | Y | Y |
| Schaakxs et al., 2017 [33] | U | U | U | U | U | U | U | U* | Y | Y |
| Ozer et al., 2018 [34] | U* | Y | U | U | U | U | U | Y | Y | Y |
| Y = There are explanations of the assignment | Y = reports sex, weight and species | Y = There are explanations of allocation concealment | Y = There are explanations of how the accommodation was hidden | Y = There are explanations of blinding of caregivers and/or researchers | Y = There are explanations of blinded analysis of animals | Y = Informs blinded evaluation of results | Y = Animal losses explained or states no animal losses. | Y = Reports positive and negative results | Y = Nothing unsual (bias) | |
| U = No explanation of the assignment. U* = mentions “randomly allocated” |
U = Lack of baseline data | U = No explanation of allocation concealment | U = No explanation of accommodation concealment | U = No explanations of blinding of caregivers and/or researchers | U = No explanations of blinded analysis of animals |
U = No information from blinded evaluation of the results. | U = Animal losses not declared. U* = Declared postoperative condition. |
U = Does not report negative results | ||