Table 1.
Clinical characteristics of the study cohort and subdivided respect to T2D status.
| Variable | Whole NASH Cohort (n = 140) | NASH Patients without T2D (n = 47) | NASH Patients with T2D (n = 93) | p Value |
|---|---|---|---|---|
| Age (years) | 59 (10) | 55 (12) | 60 (9) | 0.001 |
| Female gender, n (%) | 81 (58%) | 25 (53%) | 56 (60%) | 0.542 |
| BMI (kg/m2) | 32 (5) | 31 (5) | 32 (5) | 0.209 |
| Waist circumference (cm) | 108 (12) | 105 (13) | 109 (11) | 0.120 |
| Fasting glucose (mg/dL) | 129 (55) | 94 (12) | 147 (60) | <0.001 |
| HbA1c (%) | 6.5 (1.4) | 5.5 (0.4) | 7.1 (1.5) | <0.001 |
| HOMA-IR | 7.41 (6.40) | 5.40 (2.99) | 8.69 (6.08) | 0.007 |
| Triglycerides (mg/dL) | 153 (113–206) | 136 (114–170) | 161 (113–216) | 0.088 |
| Cholesterol LDL (mg/dL) | 116 (37) | 130 (33) | 109 (37) | 0.001 |
| Cholesterol HDL (mg/dL) | 49 (12) | 52 (12) | 47 (11) | 0.036 |
| ALT (UI/L) | 46 (31–71) | 55 (34–103) | 45 (30–63) | 0.059 |
| AST (UI/L) | 42 (29–59) | 44 (30–59) | 41 (27–59) | 0.615 |
| GGT (UI/L) | 73 (41–160) | 58 (40–150) | 74 (41–166) | 0.681 |
Values are mean (standard deviation), number (%), or median (Q1–Q3). BMI: body mass index; HOMA-IR: Homeostasis model assessment of insulin resistance; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase. p values are obtained between “without T2D” and “with T2D” group’s comparison.