Figure 2.

Administration of FIR therapy is effective against SMC and fibroblast activity in OAT-induced chronic allograft vasculopathy. (A) Immunohistochemistry to assess proliferated SMCs (αSMA) and fibroblasts (S100A4) in rat thoracic aortas from donor PVG/Seac rats. The lumen is uppermost in all sections; the images are 200× magnified. Similar regions are shown as enlarged images (400× magnification) in the black corners. The brown signal indicates αSMA- and S100A4-positive cells. (B,C) The quantification of cells in high power field (HPF) is displayed in (B,C). The graphs demonstrate the accumulation of cells in the aortas of rats. The results are expressed as the mean ± SD. * p < 0.05 was taken into consideration statistically considerable.