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. 2022 May 7;10(5):1089. doi: 10.3390/biomedicines10051089

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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FIR therapy decreased splenic T lymphocytes, plasma cells, B lymphocytes, and macrophages activation in the OAT-ACI/NKyo rats. (A) The spleens were dissected from experimental rats after they were sacrificed. The weight of the spleen was analyzed and presented in a bar graph in g/g BW. The results are expressed as the mean ± SD. * p < 0.05 was taken into consideration statistically considerable. (B) Immunohistochemistry was used to analyze the accumulation of splenic CD11b⁺ macrophages in the OAT-recipient ACI/NKyo rats (CA, central artery; PALS, periarterial lymphatic sheath; GC, germinal center;). The red triangle arrow heads are CD11b⁺ macrophages. The images in the column are 200× and 400× magnification, respectively. (C) Immunohistochemistry was used to analyze accumulation of splenic CD8⁺ cytotoxic T cells and CD4⁺ helper T cells in the recipient rats. The images are presented in 200× and 400× magnification. The CD4⁺ and CD8⁺ cells are indicated by red arrow heads. (D) The splenic CD20⁺ B cells and CD138⁺ plasma cells accumulation in the OAT-recipient rats (MZ, mantle zone and VS, venous sinuses). The images in the column are 200× and 400× magnification, respectively. The red triangle arrow heads indicate CD138⁺ cells. The cell nuclei were counted with hematoxylin.

FIR therapy decreased splenic T lymphocytes, plasma cells, B lymphocytes, and macrophages activation in the OAT-ACI/NKyo rats. (A) The spleens were dissected from experimental rats after they were sacrificed. The weight of the spleen was analyzed and presented in a bar graph in g/g BW. The results are expressed as the mean ± SD. * p < 0.05 was taken into consideration statistically considerable. (B) Immunohistochemistry was used to analyze the accumulation of splenic CD11b⁺ macrophages in the OAT-recipient ACI/NKyo rats (CA, central artery; PALS, periarterial lymphatic sheath; GC, germinal center;). The red triangle arrow heads are CD11b⁺ macrophages. The images in the column are 200× and 400× magnification, respectively. (C) Immunohistochemistry was used to analyze accumulation of splenic CD8⁺ cytotoxic T cells and CD4⁺ helper T cells in the recipient rats. The images are presented in 200× and 400× magnification. The CD4⁺ and CD8⁺ cells are indicated by red arrow heads. (D) The splenic CD20⁺ B cells and CD138⁺ plasma cells accumulation in the OAT-recipient rats (MZ, mantle zone and VS, venous sinuses). The images in the column are 200× and 400× magnification, respectively. The red triangle arrow heads indicate CD138⁺ cells. The cell nuclei were counted with hematoxylin.