Table 3.

Description and frequencies of reads and haplotypes of the altered stop codons identified in more than 10% of the 50 patients studied.

HBX Stop Codon	IDs	N Patients (%)	Median % Reads/Patient (IQR)	Median % HPL/Patient (IQR)
95	2, 3, 7, 8	5 (10)	0.4 (0.3–0.5)	5.9 (5.3–8.3)
109	28, 29, 30, NA	9 (18)	0.5 (0.4–0.6)	6.7 (4.3–16.7)
125	18, NA	8 (16)	1.9 (0.6–3.8)	3.8 (2.2–5.8)
128	37, 38, 41	15 (30)	0.4 (0.3–0.6)	8.3 (5.6–18.3)
129	6, 11, 23, 25, 34, 35, 36, 39, 40	21 (42)	0.5 (0.4–0.6)	7.1 (4.8–11.1)
132	45, 46, 49, 57	5 (10)	0.5 (0.5–0.8)	2.6 (2.6–4.3)
135	14, 15, 22, 47, 48, 51, 53, 55, 80, 81, 87, 90, 100	14 (28)	2.0 (0.5–4.9)	6.1 (3.0–11.8)
138	59	5 (10)	0.6 (0.6–0.7)	8.3 (4.8–8.3)
149	63, 72	5 (10)	0.7 (0.4–1.0)	4.5 (4.2–4.8)
156	12, 13, 27, 58, 76, 82, 89	7 (14)	2.6 (0.7–7.3)	7.1 (5.5–7.7)
179	85	10 (20)	0.4 (0.4–0.8)	4.1 (2.8–5.1)
180 *	75, 86, 98	5 (10)	0.9 (0.6–1.2)	5.1 (3.6–5.9)
207 *	101, NA	6 (12)	0.5 (0.4–0.6)	3 (2.4–4.4)
360 *	70, 92	5 (10)	0.6 (0.6–1.1)	2.6 (2.3–4.3)
362 *	74, 78, 84, 88	24 (48)	1.6 (0.8–2.1)	5.8 (3.1–10.7)

Abbreviations: HBX indicates hepatitis B X open reading frame; IDs, code to identify single insertion or deletion, or combinations of them, described in Table S3; N, number; IQR, interquartile range; HPL, haplotypes; NA, haplotype/s without insertions and/or deletions. * Putative stop codons of the HPL without stop codon in HBX, obtained by extension of those HPL with reference sequences V01460 (for genotype D HPL) and X02763 (for genotype A HPL) and continue translation.