Table 2.

Mutations in genes other than KIT reported in systemic mastocytosis.

Gene	Exon	Gene Mutations
ASXL1	6	S135C [12]
	8	G219V [12]
	12	Y591* [80]	I641fs [13]	P698Afs* [32]	I919Yfs* [29]	H1008Tfs* [29]
		E602* [29]	G642fs [12]	R786Efs* [29]	P920Tfs* [80]	G1026Dfs* [29]
		A611T [29]	G643Wfs* [13]	D820Mfs* [29]	R965_G966del [12]	I1220F [80]
		I617Pfs* [32]	G646Wfs* [29,81]	T844fs [12]	Y974* [32]	G1397S [29]
		H630fs [12]/Gfs* [29]	G646Afs* [29]	S846Vfs* [81]	I980Kfs* [32]	A1521S [12]
		E635Rfs* [13,29,32]	R693* [13]	P849Lfs* [29]	E997* [29]	*1542fs [13]
CBL	8	Q367dup [80]	Y371C [29]/H [29]/S [29]		M374K [29]	L380P [10,29,82]
		C384R [12]/Y [29]	M400K [10,32]	C404Y [10,29]	W408C [10,32]
	9	G413D [29]	R420Q [10,29]	I423N [29]
	11	R550W [12]
DNMT3A	3	E30A [80]
	4	N90S [12]
	8	R320* [12,29]
	10	A380V [12]	K420* [12]
	15	W581C [12]	L594Cfs* [29]	R598* [29]	D600Afs* [29]
	16	S638C [12]
	17	S663L [12]
	18	S714F [12]	R720L [12]
	19	E733G [29]	F755S [12]	R771G [29]/Q [80]
	23	N879D [13]	R882C [12,13]/H [12,13,80]
EZH2	3	L50Wfs* [13]
	5	I146T [13]
	7	S220F [32]
	8	R288* [32]
	14	Q545* [13]
	15	R583Q [13]	N608K [13]
	17	F672L [29]
	18	R690C [29]	H694R [40]
JAK2	14	V617F [12,29,32]	S605Y [12]
KRAS	2	V14I [83]
	3	Q70H [12]
	5	I187N [12]
NRAS	2	G12S [29]	G12D [29,84]	G13D [84]
	3	Q61L [29]
RUNX1	4	L56S [29]	P86fs [13]		E88Rfs* [13]	S94I [29]
		D96Gfs [85]	R107C [13]		N109T [13]/del [29]	F116L [12]
	5	S141L [29]	A142T [13]		N146K [12,13]	R162K [13,29]
	7	V238Gfs* [13]
SF3B1	5	Y141C [12]
	14	R625C [29]	W658C [29]	T663I [29]	K666N [29]/T [13,32]
	15	K700E [13,29,83]	A711D [86]
SRSF2	1	V18L [10]	P95 A [13]/H [10,32,85]/L [10]/R [12,13]/T [87]
TET2	3	L34F [29]	Q321* [83]	P562Tfs* [29]	Q729* [32]	Q933* [51]
		H192Y [13]	E368* [13]	N595Ifs* [51]	Q731* [51]	Q939* [29]
		V218Wfs* [32]	Q373Rfs* [51]	P612fs [12]	Q734* [51]	K948Nfs* [83]
		Y234* [51]	P409Lfs* [80]	L615Sfs* [29]	Q752_fs* [29]	W954* [29]
		R248Q [29]	G429R [29]	Y620fs [12]	L757Tfs* [29]	Q958Tfs* [29]
		S254Rfs* [51]	L431* [51]	Y634* [29]	L806Rfs* [29]	Q963* [29]
		E259Gfs* [29]	E452Rfs* [29,88]	Q652* [29]	Q810* [29,88]	S972Ffs* [29]
		N275Ifs* [12,13]	D527Gfs* [29]	Q652Sfs* [80]	N837Yfs* [32]	C1016Wfs* [29,88]
		Q278* [29]	Q530* [29]	Q659Rfs* [29]	L840* [51]	Q1020* [80]
		T279fs [12]	E537Sfs* [29]	Q684Nfs* [29]	T849Hfs* [89]	I1024Qfs* [51]
		N281* [29]	R550* [29]	Q705Sfs* [29]	Y867H [29]	P1061Qfs* [51]
		R282G [29]	H558Lfs* [51]	A727S [12]	V872Cfs* [29]	Q1084P [29]
	4	D1143Mfs* [32,51]
	5	Q1170* [88]
	6	H1219D [32]	Y1245Lfs [85]	S1246* [51]	Y1255fs [12]
	8	Y1337* [80]	A1341E [85]
	9	Y1351* [51]	R1359 C [88]/H [29]	S1369L [29]	H1380Y [29]	D1384V [29]
		Q1389* [51]	T1393I [29]
	10	R1465* [29]	R1467G_fs* [29]	K1493fs [12]
	11	L1515Ffs* [51]	M1615* [89]	V1718L [29]	L1819* [29]	N1890S [12]
		L1531A_fs* [29,88]	Q1652Hfs* [29]	P1723S [29]	I1873T [80]	R1891G [29]
		K1533* [29]	Y1679L_fs* [29]	D1750Efs* [51]	E1879* [29]	F1901Lfs* [51]
		E1555R_fs* [29]	Q1680* [29]	N1765* [29]	H1881L [29]/R [29,51,88]	Y1902C [29]
		Y1598Sfs* [29]	S1688_fs* [29,51,88]	M1800Dfs* [51]	T1884A [29]	H1904R [80]
		S1611Y [12]	M1701I [29]	H1817Pfs* [29]	L1886S [29]	H1912Y [13]

*: Stop codon resulting in an incomplete protein.