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. 2022 May 13;11(10):1639. doi: 10.3390/cells11101639

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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High levels of non-classical monocytes associate with improved PFS in patients with ER-negative primary tumors and with improved OS in patients with ER-positive primary tumors. Kaplan–Meier curves of progression-free survival (PFS; left) and overall survival (OS) from baseline (right) according to the levels of indicated monocyte subpopulation in patients with MBC stratified for primary tumor ER status. (A) CD14⁺⁺CD16⁻ classical monocytes. (B) CD14⁺⁺CD16^+/++ intermediate monocytes. (C) CD14⁺CD16⁺⁺ non-classical monocytes. N = 17 ER-positive and N = 7 ER-negative for all subpopulations. Statistics by log-rank test, p-values < 0.05 highlighted in bold.