Table 3.
Examples of nanoparticles responsive to biochemical features of the tumor microenvironment and including additional functions.
| Carrier | Drug | Additional Functions | Mechanism | Responsive to | Ref. |
|---|---|---|---|---|---|
| Upconversion nanoparticle-albumin |
Doxorubicin Chlorin 6, Fe2+ |
Photodynamic Chemodynamic |
Production of ROS by NIR and H2O2 | NIR irradiation Low pH |
[43] |
| Copolymer nanoparticle |
Doxorubicin prodrug Chlorin 6 |
Photodynamic Chemodynamic |
Production of ROS by NIR | NIR irradiation Reductive conditions |
[44] |
| Nano-donuts | Doxorubicin Prussian Blue Fe3+ ion |
Chemodynamic Photothermal MRI |
Production of ROS by H2O2 Induction of hyperthermia |
NIR irradiation, Presence of ROS |
[45] |
| PEG-PEI-based nanoparticle |
Docetaxel IR825 |
Photothermal | Induction of hyperthermia |
NIR irradiation, Low pH |
[46] |
| Semiconducting polymer | Doxorubicin prodrug |
Photothermal | Induction of hyperthermia |
NIR irradiation, Low pH |
[47] |
| Dendrimer/ Lentinan nanoparticle |
Paclitaxel | Photodynamic | Production of ROS by NIR | NIR irradiation, Low pH, Reductive conditions, Presence of ROS |
[48] |