Table 10.

Examples of nanoparticles for applications in multidrug resistant tumors.

Carrier	Nucleic Acid	Drug	Natural Compound	Small-Molecule Inhibitor	Targeting Moiety	Ref.
Mesoporous silica nanoparticle	P-gp siRNA					[207]
Prodrug nanoparticle	P-gp siRNA	Paclitaxel				[208]
Chitosan-PEI nanoparticle	P-gp shRNA	Paclitaxel			Folate	[209]
Albumin nanoparticle	P-gp siRNA	Doxorubicin			Cetuximab	[210]
RNA nanoparticle	miR-122	Paclitaxel			Asialoglycoprotein	[211]
Silica/gold nanoparticle	miR-let-7a	Paclitaxel			Hyaluronic acid	[212]
Mesoporous silica nanoparticle	GNC5 siRNA	Doxorubicin			Hyaluronic acid	[213]
Prodrug-PLGA nanoparticle	CCAT2 siRNA	Docetaxel			Transferrin	[214]
Carbon/silica nanoparticle		Doxorubicin		HM30181A	Fucoidan	[216]
Nanomicelle		Paclitaxel		Ritonavir	Hyaluronic acid	[217]
Liposome		Paclitaxel + doxorubicin				[218]
DSPE-PEG nanobubble		Paclitaxel + gemcitabine				[219]
Liposome +hydrogel		Paclitaxel + gemcitabine			PR_b peptide	[221]
Nanocrystal + hydrogel		Paclitaxel + niclosamide				[222]
Lipid nanocapsule		Paclitaxel + salinomycin				[223]
Mesoporous silica nanoparticle		Cisplatin + gemcitabine			α-mucin 1	[224]
PEG-PLGA nanoparticle		Paclitaxel	Curcumin		cRGD	[225]
Polymeric nanoparticle		Paclitaxel	Resveratrol			[226]
PEG-PLGA nanoparticle		Paclitaxel	Etoposide			[227]
Solid lipid nanoparticle		Paclitaxel	Naringenin		cRGD	[228]
PEG-PLGA nanoparticle		Paclitaxel + verteporfin	Combretastatin			[229]
Stealth nanoparticle		Paclitaxel		17-AAG		[230]
Calcium carbonate nanoparticle		Paclitaxel		Gefitinib		[231]
Albumin nanoparticle		Paclitaxel		Carfilzomib		[232]
Copolymer micelle	STAT3 siRNA	Paclitaxel			Hyaluronic acid	[233]
PEI-PLGA nanoparticle	VEGF siRNA	Paclitaxel				[234]
Liposome	Twinfilin 1 siRNA	Paclitaxel				[235]
Polymeric nanoparticle	miR-124	Paclitaxel			Hyaluronic acid	[237]
Lipid nanoparticle	EGFR siRNA	Paclitaxel		Gefitinib	LHRH	[238]