Table 1.

miRNAs dysregulated in MM.

Activity/Pathway Affected	miRNA	Status 1	Target	References
Enhances PI3K/Akt pathway	miR-20a		EGR2, PTEN	[29,30]
	miR-21		PIAS3	[31]
	miR-25-3p		PTEN	[32]
	miR-221/222		PUMA, PTEN, CDKN1B, p27	[33]
	miR-410		KLF10	[34]
Enhances mTOR pathway	miR-19b		TSC1	[35,36]
	miR-135b, miR-642a		DEPTOR	[37]
Related to a hypoxia phenotype	miR-210		DIMT1	[38,39]
	miR-1305		MDM2, IGF1, FGF2	[40]
Disrupts PRC2 activity	miR-124		EZH2	[41]
Modulates microenvironment	miR-146a		Not described	[42]
	miR-155		Not described	[43]
Promotes proliferation, circulating miRNAs	miR-17-92		BIM	[35]
	miR-221/222			[33]
Circulating miRNA	miR-1		Not described	[44]
	miR-133a/b		Not described	[44]
	miR-135b		HIF1A	[45,46]
	miR-146b		Not described	[47]
	miR-181a		BCL2L11	[48,49]
	miR-214		CD276	[50]
Represses JAK/STAT pathway	miR-125b		IL6R, STAT3, MALAT1	[51,52]
	miR-331-3p		IL6R	[53]
	miR-375		PDPK1	[54]
	miR-451		IL6R	[55]
	let-7b-5p		IGF1R	[56]
Regulates cyclin activity	miR-26a		CDK6	[57]
	miR-28-5p		CCND1	[58]
	miR-30a-3p		MAF	[59]
	miR-338-3p		CDK4	[60]
	miR-340-5p		CCND1, NRAS	[61]
	miR-196a/b		CCND2	[44]
Regulates proliferation	miR-22		c-Myc	[62]
	miR-29a		c-Myc	[63]
	miR-34a		BCL2, CDK6, NOTCH1, c-Myc, MET, IL6R	[52,64,65]
	miR-193a		MCL1	[66]
	miR-497		BCL2	[67]
	miR-767-5p		MAPK4	[68]
	miR-874-3p		HDAC1	[69]
	miR-1180		YAP	[70]
Prevents angiogenesis	miR-15a/16		BCL2, VEGF, IL17	[71]
Regulates acetylation	miR-29b		HDAC4, MCL1	[72]
Regulates transcriptional activity	miR-509-5p		FOXP1	[73]
	miR-1271-5p		SOX13, HGF	[74,75]
Prevents hypoxia phenotype	miR-199a-5p		HIF1A, VEGFA	[76]
Prevents osteolytic activity	miR-342		RUNX2	[77]
	miR-363		RUNX2	[77]

¹ Arrow up indicates overexpression of the miRNA, and arrow down indicates underexpression of the miRNA.