Table 2.
lncRNAs that are dysregulated in MM.
| lncRNA | Status 1 | Target | Activity/Pathway Affected | References |
|---|---|---|---|---|
| ANGPLT1-3 |
|
miR-30a-3p | ceRNA | [59] |
| BM742401 |
|
Not described | Inhibit myeloma cell migration, biomarker | [84] |
| CRNDE |
|
miR-451 | ceRNA | [55,85] |
| DARS-AS1 |
|
RBM39 | Enhances mTOR pathway, hypoxia phenotype | [86] |
| H19 |
|
miR-29b | ceRNA, biomarker | [87] |
| HOTAIR |
|
Not described | Enhances JAK/STAT pathway | [88] |
| MALAT1 |
|
HMGB1, miR-509-5p, miR-1271 |
Contributes to genomic stability, ceRNA, biomarker | [73,74,89,90] |
| MEG3 |
|
miR-181a | Promotes osteogenic differentiation, biomarker, ceRNA | [91] |
| MIAT |
|
miR-29b | Inducible by bortezomib, ceRNA, biomarker | [92] |
| NEAT1 |
|
miR-214, miR-193a |
Downregulates genes involved in DNA repair, enhances Wnt/β-catenin pathway, ceRNA | [50,66,93,94] |
| NR_046683 |
|
Not described | Biomarker | [95] |
| OPI5-AS1 |
|
miR-410 | ceRNA | [34] |
| PDIA3P |
|
c-Myc | Regulates proliferation | [96] |
| RUNX2-AS1 |
|
RUNX2 pre-mRNA |
Promotes osteogenesis | [97] |
| SMILO |
|
Not described | Regulates proliferation | [98] |
| SNHG16 |
|
miR-342 | ceRNA | [99] |
| UCA1 |
|
miR-1271-5p, miR-331-3p | ceRNA | [61,75] |
| XLOC_013703 |
|
IKKA | Represses NF-κB pathway | [100] |
1 Arrow up indicates overexpression of the lncRNA, and arrow down indicates underexpression of the lncRNA.