Table 4.
Non-coding RNAs implicated in SCC.
| Non-Coding RNA | Samples and Methods | Status | Proposed Role | Limitations | Reference |
|---|---|---|---|---|---|
| miRNAs | |||||
| miR-10b | - Cell line |
Upregulated | Tumor promoter |
Lack of evidence on animal models | [111] |
| lncRNAs | |||||
| RP11-493L12.5 | 28 Tissue |
Upregulated | Unknown | Small sample size | [112] |
| KB-1410C5.3/lnc-GRHL2 | Downregulated | Unknown | |||
| circRNAs | |||||
| circ_0070934 | 38 Tissue Cell line |
Upregulated | Tumor promoter |
Downstream targets of miRNAs sponged by this circRNA are still unknown in SCC |
[113] |
| - Cell line |
Upregulated | Tumor promoter |
Tissue from patients is needed to asses clinical value | [114] | |
| circ_EPSTI | 28 Tissue |
Upregulated | Unknown | Small sample size | [112] |
| circ_IFFO2 | Downregulated | Tumor promoter |
|||
| circ_0001360 | 3 Tissue |
Downregulated | Tumor suppressor |
Small sample size | [115] |