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. 2022 May 19;14(10):2492. doi: 10.3390/cancers14102492

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The antitumor efficacy of apatinib and exerted exosome inhibition in vivo. (A) Bioluminescent imaging for RKO-luc orthotopic xenograft colon tumors in the control vs. apatinib group (n = 5 per group). (B–D) Comparison of the tumor volume, tumor weight, and bioluminescence between the control and apatinib group. (E) NTA showed the concentrations of serum exosomes isolated from the control and apatinib group. (F) Quantification of the serum exosomal protein levels obtained from the control and apatinib treatment mice. * p < 0.05, ** p < 0.01, and *** p < 0.001.