Figure 1.

Neoangiogenesis in tumor. A tumor needs nutrients and oxygen (O₂) to support neoplastic expansion. The provision of these needs requires the establishment of a new vascular network through the process of angiogenesis. Angiogenesis consists of the assembly of endothelial cells in the form of tubes from existing vessels. During hypoxia and tumor growth, the nuclear translocation of HIF1α induces the expression of pro-angiogenic factors such as VEGF, EGF, or FGF... Angiogenic factors are able to activate and stimulate endothelial cells through membrane receptors. Indeed, these signals participate in the proliferation, invasion, migration, survival, and increase in the permeability of the vessels. Inspired from the Cancer Research Product Guide Edition 3, 2015.