Table A4.
Table with studies’ characteristics (title, first author, publication year, sample size, sample characteristics, study aim and quality assessment).
| Title | Author Year | Study Design | Sample Size | Sample Characteristics | Study Aim | Quality Assessment |
|---|---|---|---|---|---|---|
| Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network |
A. Dagher 2017 |
Case-control | 491 | UCPPS: 120 male and 139 female participants (Mean age = 43.3 y); Race: 229 white and 10 black; Ethnicity: 19 Hispanic and 239 Non-Hispanic HC group: 50 male and 75 female participants (Mean age = 42.5 y); Race: 90 white and 16 black; Ethnicity: 8 Hispanic and 117 Non-Hispanic PC group: 32 male and 75 female participants (Mean age = 41.6 y); Race: 76 white and 12 black; Ethnicity: 10 Hispanic and 96 Non-Hispanic |
To compare urinary levels of VEGF/VEGF-R1 and NGAL, MMP-9/NGAL complex between UCPPS, patients and HC and PC patients while correlating them with symptom severity | 8/9 |
| Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder | A. Furuta 2018 | Case-control | 88 | OAB: 28 patients (7 male; 21 female); Mean age (57.7 y); BPS: 30 patients (9 male; 21 female); Mean age (60.2 y); IC: 30 patients (9 male; 21 female); Mean age (63.5 y) |
To investigate the contributing factors of chronic inflammation in IC patients | 7/9 |
| Angiogenesis in bladder tissues is strongly correlated with urinary frequency and bladder pain in patients with interstitial cystitis/bladder pain | A. Furuta 2019 | Case-control | 36 | Control: 12 females (Mean age 56.7 y); BPS: 12 females (Mean age 53.3 y); IC: 12 females (Mean age 57.0 y) |
To clarify the correlation among bladder inflammation, angiogenesis, fibrosis and urothelial denudation using immsunohistochemistry, OSSI, OSPI and VAS pain scores | 6/9 |
| Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies | Y. Akiyama 2019 |
Case-control | 42 | IC: 12 patients (Mean age: 70.5 y) BPS: 11 patients (Mean age: 58.8 y) Hypersensitive bladder: 10 patients (Mean age: 63.5 y) Control group: 9 patients (Mean age: 64.6 y) |
To perform transcriptome of BPS/IC subtypes and non-BPS/IC subtypes controls, providing the basis of a molecular taxonomy of BPS/IC, and explore biological pathways specifically affected in each subtype | 7/9 |
| Association of Longitudinal Changes in Symptoms and Urinary Biomarkers in Patients with Urological Chronic Pelvic Pain Syndrome: A MAPP Research Network Study | R. Roy 2021 | Prospective cohort | 216 | UCPPS patients: 116 female and 100 male patients | To analyze a series of non-invasive biomarkers for their ability to objectively monitor the longitudinal clinical status of UCPPS patients | 7/9 |
| Relationship of Bladder Pain with Clinical and Urinary Markers of Neuroinflammation in Women with Urinary Urgency Without Urinary Incontinence | A. Soriano 2021 |
Cross-sectional | 101 | NBP (Mean age = 48.9): Caucasian: 32 patients; African American: 4 patients; Other: 2 patients BP (Mean age = 44.6): Caucasian: 55 patients; African American: 5 patients; Other: 2 patients |
To assess if bladder pain is associated with presence of neurogenic inflammation in the bladder wall and neuroinflammatory biomarkers in the urine in women with urinary urgency without incontinence | 8/8 |
| Relationship of Pain Catastrophizing With Urinary Biomarkers in Women With Bladder Pain Syndrome | A. Soriano 2021 | Cohort | 62 | Women who met AUA criteria of bladder pain syndrome | To assess greater pain catastrophizing with higher urinary biomarkers (VEGF and BDNF) levels in women with bladder pain syndrome | No quality assessment possible |
Abbreviations: BP—Bladder Pain group; BPS—Bladder Pain Syndrome; F-GUPI—Female Genitourinary Pain Index; HC—Healthy Controls; HSB—Hypersensitive Bladder; IC—Interstitial Cystitis; NBP—Non-Bladder Pain group; OAB—Overactive Bladder; OSPI—O’Leary—Sant Problem Indexes; OSSI—O’Leary−Sant Symptom Indexes; PC—Positive Control (non-urological associated syndrome); UCPPS—Urological Chronic Pelvic Pain Syndrome; VAS—Visual Analogue Scale; VEGF—Vascular Endothelial Growth Factor; VEGF-R1—Vascular Endothelial Growth Factor-receptor.