Figure 3.

The P53 mRNA can be regulated post-transcriptionally (A) by miRNAs and RNA-binding proteins (RBPs) which modify the P53 transcriptional program in a stimulus-specific manner. The P53 miRNA regulation can be positive if miRNAs bind P53 inhibitors or can be negative if the miRNAs target is P53 mRNA. In addition to miRNA action, the P53 post-transcriptional program is also co-regulated, both negatively and positively, by RBPs that bind 5′UTR; 3′UTR; CDS of TP53. Some proteins modify P53 post-translationally. The figure (B) shows the P53-modifications of specific amino acid residues divided into Covalent Modification, Ubiquitination, and cofactors.