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. 2022 May 13;11(10):1631. doi: 10.3390/cells11101631

Figure 9.

Figure 9

Schematic mechanism of P53–miRNA interaction at multiple levels. MiRNAs directly target P53 by binding the 3′UTR of P53 mRNA. The interaction downregulates the translation of P53 mRNA (hit 1). In a regulatory circuit P53 increases or decreases the expression of miRNAs by inhibiting regulators (hit 2). Furthermore, some miRNAs targeting P53 regulators vary P53 outcomes (hit 3). If the regulators are positive, P53 outcomes culminate in decreases, or, on the other hand, negative regulators lead to a P53 increase.