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. 2022 Apr 21;12(5):1046. doi: 10.3390/diagnostics12051046

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representative in vivo Cr-CEST images of control and cisplatin-treated mice. The upper row displays the MTR asymmetry map of MTR_conv at 1.8 ppm, whereas the bottom row displays the MTR asymmetry map of AREX. The left column represents the control (A,D), the central column represents the low dose (B,E), and the right column represents the high dose (C,F). MTR, magnetization transfer ratio; MTR_conv, conventional analysis metric magnetization transfer ratio; AREX, apparent exchange-dependent relaxation; and Cr-CEST, creatine chemical exchange saturation transfer.