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. 2022 May 19;11(10):1695. doi: 10.3390/cells11101695

Figure 3.

Figure 3

Hypoxia-induced autophagy is mediated by PI3Ks. (A) Detection of acidic/lysosomal compartments by Lysotracker and confocal analysis (scale bar: 15 µm) and (B) LAMP1 and SQSTM1/p62 protein levels in DCs exposed to hypoxia for 24 h and 48 h, respectively, and treated in the last 6 h with SAR405 and Wortmannin. (C) Vps34 protein levels in DCs exposed to hypoxia for 24 h and treated in the last 6 h with SAR405. All blots shown are representative of at least three independent experiments. β-actin as loading control. * indicates statistically significant differences (p ≤ 0.05; n = 3).