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. 2022 May 12;14(10):2393. doi: 10.3390/cancers14102393

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Correlation between MDK serum levels and efficacy. (A) Soluble MDK serum levels were quantified by ELISA at 3 timepoints throughout the study period: at baseline, after the concomitant phase of treatment, and after unequivocal progression of the disease. MDK levels are represented as a box plot with the median (dark line), the 25% and 75% quartiles (box), and 95% CI interval (cap lines). p-values were obtained by paired t-test. (B) PFS estimated by Kaplan–Meier stratified by the serum MDK levels. (C) OS estimated by Kaplan–Meier stratified by the serum MDK levels.