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. 2022 May 19;11(10):1691. doi: 10.3390/cells11101691

Figure 4.

Figure 4

D1 and D2 receptor agonist/antagonist-induced changes in the expression of D1DR, D2DR, and DDC. Similar to DA 50 μM, administration of DR agonists (10 μM) to SARS-CoV-2-Infected cells, either alone or in combination with DA, decreases the expression of D2DR while increasing the expression of DDC compared with SARS-CoV-2-Infected Control at 48 h post-infection. The most robust effects are produced by D2DR agonists either alone or in combination with DA. mRNA quantification was performed through real-time qPCR and calculated by the 2−ΔΔCt equation. Results are presented as mean ± SEM from at least n = 3 independent experiments, each performed in triplicate. # p < 0.05 vs. Uninfected Control (Mock), * p < 0.05 vs. SARS-CoV-2-Infected Control.