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. 2022 May 19;11(10):1691. doi: 10.3390/cells11101691

Figure 8.

Figure 8

Type-I Interferons reverse SARS-CoV-2 induced changes in the expression of DA-related genes. Compared with Uninfected Control (Mock), SARS-CoV-2 (Infected Control) at 48 h post-infection potentiates the expression of D1DR, D2DR, and DAT meanwhile downregulating TH and DDC. Treatment of SARS-CoV-2-Infected cells with Type-I Interferons (IFN-α, -β, 100 IU/mL) reduces D2DR and DAT expression while potentiating TH and DDC expression in CaLu-3 cells. mRNA quantification was performed through real-time qPCR and calculated by the 2−ΔΔCt equation. Results are presented as mean ± SEM from at least n = 3 independent experiments, each performed in triplicate. # p < 0.05 vs. Uninfected Control (Mock), * p < 0.05 vs. SARS-CoV-2-Infected Control (SARS-CoV-2).