Figure 8.

Selected drawings from the patent “Automated identification of tumor buds” (patent 10977794) awarded to the Ohio State Innovation Foundation, Columbus, OH, USA in 2021, (a) shows an illustration of a tumor segment stained with pan-cytokeratin AE1/3 under magnification (b) flow chart illustrating a method for recognizing tumor buds in an image of a tumor segment stained with pan-cytokeratin AE1/3 (c) binary image depicting tissue areas corresponding to the image of figure a (d) depicts detected nuclei within the tissue areas (e) binary image depicting identified tumor buds (f) exemplifies illustrative results of tumor bud identification, wherein the image of figure a is depicted with identifiers of tumor buds (g) flow chart illustrating a potential method for recognizing tumor buds in an image of an H&E-stained tumor segment. (reproduced from the public database at www.uspto.gov, accessed on 21 October 2021).