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. 2022 May 20;11(10):1706. doi: 10.3390/cells11101706

Figure 3.

Figure 3

Enhancement of BCAA catabolism protected the heart against MI. Mice were subjected to sham or MI operation and treated with either BCAA or BT2 post-surgery for 4 weeks. All parameters were detected at 4 weeks post-surgery. (A). Body weight of mice. (B). Cardiac BCAA levels in sham and MI mice. (C). Enhancement of BCAA catabolism by BT2 increased the left ventricular ejection fraction (LVEF) in mice with MI. (D). Heart weight in sham and MI mice. (E). Heart weight–body weight ratio in sham and MI mice. (F). Lung weight–body weight ratio in sham and MI mice. (G). Cardiac capillary density in the ischemic territory near the non-infarct area as detected by CD31 fluorescence in sham and MI mice. (H). Enhancement of BCAA catabolism by BT2 decreased cardiac fibrosis as detected by Masson staining in mice with MI. The blue staining indicates collagen and fibrosis. Values are presented as mean ± SEM. n = 6. * p < 0.05; ** p < 0.01; *** p < 0.001.