Table 1.
Main demographic, clinical and basal laboratory features of the patients included in the study.
| Global Cohort (n = 249) |
Open Surgery (n = 184) |
VATS (n = 65) |
p-Value | |
|---|---|---|---|---|
| Age, years | 66 (58–72) | 66 (59–72) | 64 (50–72) | 0.21 |
| Gender, females (%) | 67 (26.9) | 45 (24.5) | 22 (33.8) | 0.14 |
| BMI | 25.4 ± 4.1 | 25.4 ± 4.1 | NA | NA |
| Non-smokers, (%) | 48 (19.3) | 27 (14.7) | 21 (32.3) | 0.002 |
| Pack Years | 37 (16–60) | 38 (17–60) | 31 (10–60) | 0.5 |
| ASA score | I 89; II 83; | I 73; II 61; | I 16; II 22; | 0.085 |
| III 60; NA 17 | III 38; NA 12 | III 22; NA 5 | <0.000001 | |
| Surgery duration, hours | 3.0 (2.1–4.0) | 3.5 (2.5–4.5) | 2.0 (1.0–2.4) | <0.000001 |
| Hospital Stay, days | 8.0 (5.0–10.0) | 9.0 (7.0–11.0) | 5.0 (3.0–6.5) | 0.036 |
| Complications, (%) | 58 (23.3) | 49 (26.6) | 9 (13.8) | 0.21 |
| Surgery Type | <0.0001 | |||
| Lobectomy, n (%) | 139 (55.8) | 129 (70.1) | 10 (15.4) | |
| Wedge resection, n (%) | 67 (26.9) | 31 (16.8) | 36 (55.4) | |
| Pneumonectomy, n (%) | 9 (3.6) | 9 (4.9) | 0 (0) | |
| Explorative procedure, n (%) | 17 (6.8) | 6 (3.2) | 11 (16.9) | |
| Other, n (%) | 17 (6.8) | 9 (4.9) | 8 (12.3) | |
| Blood Cell Count—Indexes | ||||
| Lymphocytes, (×109/L) | 1.9 (1.5–2.4) | 1.9 (1.5–2.4) | 2.0 (1.5–2.5) | 0.77 |
| Monocytes, (×109/L) | 0.5 (0.4–0.6) | 0.5 (0.4–0.7) | 0.4 (0.3–0.6) | 0.05 |
| Neutrophils, (×109/L) | 4.6 (3.5–5.7) | 4.5 (3.5–5.7) | 4.7 (3.0–5.4) | 0.28 |
| Platelets, (×109/L) | 255 (209–333) | 256 (210–333) | 248 (208–331) | 0.80 |
| RDW, (fL) | 13.7 (12.9–14.8) | 13.8 (13.0–14.8) | 13.4 (12.7–14.8) | 0.16 |
| MPV, (fL) | 8.3 (7.6–8.9) | 8.3 (7.7–9.0) | 8.1 (7.4–8.6) | 0.42 |
| NLR | 2.3 (1.7–3.3) | 2.4 (1.7–3.3) | 2.0 (1.5–3.3) | 0.17 |
| PLR | 137 (98–189) | 137 (101–188) | 139 (94–190) | 0.79 |
| LMR | 4.4 (2.8–5.3) | 3.8 (2.8–5.0) | 4.5 (2.8–6.7) | 0.03 |
| SIRI | 1.1 (0.7–1.8) | 1.2 (0.8–1.8) | 1.0 (0.5–1.7) | 0.05 |
| AISI | 281 (163–565) | 316 (181–573) | 246 (121–448) | 0.05 |
Data are presented as mean ± standard deviation or median (interquartile range). Abbreviations: VATS: video-assisted thoracic surgery; RDW, red cell distribution width; MPV, mean platelet volume; NLR, neutrophil to lymphocyte ratio; PLR, platelets to lymphocyte ratio; LMR, lymphocyte to monocytes ratio; SIRI, systemic inflammation response index; AISI, Aggregate inflammation systemic index; NA, not available.