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Diagram showing the possible mechanism leading to the desmoplastic reaction. It can betriggered by a pancreatic tumor or chronic pancreatitis. The physiopathology of the process seems similar in pancreatic cancer and chronic pancreatitis. Furthermore, non-active stellate cells can be activated through pancreatic injury, thereby becoming the multi-stellate cells that express alpha-smooth muscle actin (that is the reason they are considered myofibroblasts) [213].
